RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Trevor, Anthony J.
SR Print(0)
ID 1179224556
T1 Sulfonamides, Trimethoprim, & Fluoroquinolones
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 12e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259641022
LK accessmedicine.mhmedical.com/content.aspx?aid=1179224556
RD 2024/04/24
AB Sulfonamides  and  trimethoprim  are  antimetabolites  that  are  selectively  toxic  to  microorganisms  because  they  interfere  with  folic  acid  synthesis.  Sulfonamides  continue  to  be  used  selectively  as  individual  antimicrobial  agents,  although  resistance  is  common.  The  combination  of  a  sulfonamide  with  trimethoprim  causes  a  sequential  blockade  of  folic  acid  synthesis.  This  results  in  a  synergistic  action  against  a  wide  spectrum  of  microorganisms;  resistance  occurs  but  has  been  relatively  slow  in  development.Fluoroquinolones,  which  selectively  inhibit  microbial  nucleic  acid  metabolism,  also  have  a  broad  spectrum  of  antimicrobial  activity  that  includes  many  common  pathogens.  Resistance  has  emerged  to  the  older  antibiotics  in  this  class,  but  has  been  offset  to  some  extent  by  the  introduction  of  newer  fluoroquinolones  with  expanded  activity  against  common  pathogenic  organisms.