RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Trevor, Anthony J.
SR Print(0)
ID 1179218463
T1 Drugs Used in Asthma & Chronic Obstructive Pulmonary Disease
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 12e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259641022
LK accessmedicine.mhmedical.com/content.aspx?aid=1179218463
RD 2024/04/19
AB Asthma  is  a  common  disease  characterized  by  airway  inflammation  and  episodic,  reversible  bronchospasm  with  severe  shortness  of  breath.  Subsets  of  clinical  asthma  may  reflect  different  pathogenic  factors  and  different  responsiveness  to  currently  available  therapies.  Drugs  useful  in  classic  allergic  asthma  include  bronchodilators  (smooth  muscle  relaxants)  and  anti-inflammatory  drugs.  Bronchodilators  include  sympathomimetics,  especially  β2-selective  agonists,  muscarinic  antagonists,  methylxanthines,  and  leukotriene  receptor  blockers.  Anti-inflammatory  drugs  used  in  asthma  include  corticosteroids,  mast  cell  stabilizers,  and  anti-IgE  antibodies.  Leukotriene  antagonists  play  a  dual  role.  Chronic  obstructive  pulmonary  disease  (COPD)  is  characterized  by  airflow  limitation  that  is  less  reversible  than  in  asthma  and  usually  follows  a  progressive  course.  However,  many  of  the  drugs  used  in  asthma  are  also  effective  in  COPD.