RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Trevor, Anthony J.
SR Print(0)
ID 1179217310
T1 Diuretics & Other Drugs That Act on the Kidney
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 12e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259641022
LK accessmedicine.mhmedical.com/content.aspx?aid=1179217310
RD 2024/04/18
AB Drugs  that  act  on  the  kidney  have  important  applications  in  renal,  cardiovascular,  and  endocrine  disorders.  These  disorders  mainly  involve  sodium  and  water  homeostasis.  Each  segment  of  the  nephron—proximal  convoluted  tubule  (PCT),  thick  ascending  limb  of  the  loop  of  Henle  (TAL),  distal  convoluted  tubule  (DCT),  and  cortical  collecting  tubule  (CCT)—has  a  different  mechanism  for  reabsorbing  sodium  and  other  ions.  The  subgroups  of  the  sodium-excreting  diuretics  are  based  on  these  sites  and  processes  in  the  nephron.  Several  other  drugs  alter  water  excretion  predominantly.  The  effects  of  the  diuretic  agents  are  predictable  from  knowledge  of  the  function  of  the  segment  of  the  nephron  in  which  they  act.