RT Book, Section A1 Costello, Jill C. A1 Rosenthal, Ann K. A2 Stone, John H. SR Print(0) ID 1180198106 T1 Calcium Pyrophosphate Deposition Disease T2 Current Diagnosis & Treatment: Rheumatology, 4e YR 2021 FD 2021 PB McGraw Hill PP New York, NY SN 9781259644641 LK accessmedicine.mhmedical.com/content.aspx?aid=1180198106 RD 2022/08/14 AB ESSENTIALS OF DIAGNOSISCalcium pyrophosphate deposition (CPPD) disease includes a spectrum of conditions ranging from asymptomatic radiographic changes to severe chronic arthritis.Acute CPP crystal arthritis, formerly known as pseudogout, shares some clinical features and treatment strategies with acute gout.The observation of calcium pyrophosphate crystals in synovial fluid is necessary for establishing a definitive diagnosis of CPPD disease.Chondrocalcinosis on radiograph helps support the diagnosis of CPPD disease.Premature CPPD disease can be a sign of a hyperparathyroidism, hemochromatosis, hypomagnesemia, or hypophosphatasia as well as familial CPPD disease.