RT Book, Section A1 Serling-Boyd, Naomi A1 Stone, John H. A2 Stone, John H. SR Print(0) ID 1180197565 T1 Cryoglobulinemia T2 Current Diagnosis & Treatment: Rheumatology, 4e YR 2021 FD 2021 PB McGraw Hill PP New York, NY SN 9781259644641 LK accessmedicine.mhmedical.com/content.aspx?aid=1180197565 RD 2024/04/23 AB Vasculitis associated with mixed cryoglobulinemia (MC) involves both small- and medium-sized vessels. The skin is the most commonly involved organ.Other frequently affected organs include the joints, peripheral nerves, and kidneys. The central nervous system, gastrointestinal tract, and lungs are involved rarely or very rarely in MC.Virtually all patients are rheumatoid factor (RF) positive.Many cases of type II cryoglobulinemia are still associated with hepatitis C virus.Lower survival rates are observed with age over 60 years, male sex, and renal involvement.