RT Book, Section
A1 Serling-Boyd, Naomi
A1 Stone, John H.
A2 Stone, John H.
SR Print(0)
ID 1180197506
T1 Polyarteritis Nodosa
T2 Current Diagnosis & Treatment: Rheumatology, 4e
YR 2021
FD 2021
PB McGraw Hill
PP New York, NY
SN 9781259644641
LK accessmedicine.mhmedical.com/content.aspx?aid=1180197506
RD 2024/04/25
AB Subacute  onset  of  constitutional  complaints  (fever,  weight  loss,  malaise,  arthralgias),  lower  extremity  nodules  and  ulcerations,  mononeuritis  multiplex,  and  postprandial  pain  are  hallmarks  of  polyarteritis  nodosa  (PAN).Cutaneous  PAN  is  a  variant  of  the  systemic  disease  in  which  vasculitis  is  limited  to  the  skin  and  often  presents  with  painful  nodules,  livedo  racemosa,  or  cutaneous  ulcerations.Patients  with  PAN  should  be  evaluated  for  hepatitis  B,  though  hepatitis  B  virus-associated  PAN  has  decreased  in  incidence  and  is  now  only  responsible  for  less  than  10%  of  cases.Angiography  may  reveal  microaneurysms  in  the  kidneys  or  gastrointestinal  tract.Biopsies  of  the  skin  and  peripheral  nerves  (with  sampling  of  the  adjacent  muscle)  are  the  least  invasive  ways  of  confirming  the  diagnosis  histopathologically.