RT Book, Section A1 Guilpain, Philippe A1 Maria, Alexandre A2 Stone, John H. SR Print(0) ID 1180196036 T1 Adult-Onset Still Disease T2 Current Diagnosis & Treatment: Rheumatology, 4e YR 2021 FD 2021 PB McGraw Hill PP New York, NY SN 9781259644641 LK accessmedicine.mhmedical.com/content.aspx?aid=1180196036 RD 2024/03/29 AB Quotidian fever, frequently greater than 39°C.Evanescent, salmon-colored macular rash on the trunk and extremities, often coincident with fever spikes, typically in the late afternoon or evening.Other main clinical features are pharyngitis, polyarthralgia, lymphadenopathy, splenomegaly, and serositis.Common laboratory abnormalities include a leukocytosis, elevations of the acute phase reactants (erythrocyte sedimentation rate and C-reactive protein), and dramatic increases in the serum ferritin level.The most striking complication of adult-onset Still disease (AOSD) is reactive hemophagocytic lymphohistiocytosis (RHL), formerly named macrophage activation syndrome.