RT Book, Section
A1 Dhodapkar, Madhav V.
A1 Banchereau, Jacques
A2 Kaushansky, Kenneth
A2 Prchal, Josef T.
A2 Burns, Linda J.
A2 Lichtman, Marshall A.
A2 Levi, Marcel
A2 Linch, David C.
SR Print(0)
ID 1178737663
T1 Dendritic Cells and Adaptive Immunity
T2 Williams Hematology, 10e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260464122
LK accessmedicine.mhmedical.com/content.aspx?aid=1178737663
RD 2024/04/19
AB SUMMARYDendritic  cells  (DCs)  are  a  multifunctional  group  of  cells  that  serve  as  sentinels  of  the  immune  system  and  thus  regulate  many  immune  functions.  DCs  play  a  central  role  in  initiating  adaptive  immune  responses  to  pathogens  and  initiating  antitumor  immune  responses.  DC  receptors  sense  environmental  stimuli  and  can  respond  rapidly  to  both  foreign  pathogens  and  danger  signals  derived  from  tissue  damage  or  immune  complexes.  Through  their  capacity  to  present  antigen  to  T  cells  in  immune-activating  or  immune-dampening  contexts,  DCs  can  both  induce  T-cell  proliferation  (activation)  or  lack  of  activation  (tolerance).  In  this  way,  DCs  help  regulate  immune  responses  mediated  by  T  cells  and  B  cells  of  the  adaptive  immune  system.  This  chapter  describes  the  varied  types  and  functions  of  this  important  class  of  cells.