RT Book, Section A1 Zhou, Liang A1 Grant, Steven A2 Kaushansky, Kenneth A2 Prchal, Josef T. A2 Burns, Linda J. A2 Lichtman, Marshall A. A2 Levi, Marcel A2 Linch, David C. SR Print(0) ID 1178737101 T1 Cell-Cycle Regulation and Hematologic Disorders T2 Williams Hematology, 10e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260464122 LK accessmedicine.mhmedical.com/content.aspx?aid=1178737101 RD 2024/03/29 AB SUMMARYComplex feedback pathways regulate the passage of cells through the G1, S, G2, and M phases of the growth cycle. Two key checkpoints control the commitment of cells to replicate DNA synthesis and to mitosis. Many oncogenes and defective tumor-suppressor genes promote malignant change by stimulating cell-cycle entry or disrupting the checkpoint response to DNA damage. Advances in the understanding of genetic and epigenetic mechanisms of gene regulation provide the basis for novel therapeutic approaches. This chapter presents the pathways and the genetic and epigenetic alterations that regulate cell replication and highlights the various oncogenes and tumor-suppressor genes that are involved in hematologic malignancies.