RT Book, Section A1 V.B. Reddy, Vishnu A1 Morlote, Diana A2 Kaushansky, Kenneth A2 Prchal, Josef T. A2 Burns, Linda J. A2 Lichtman, Marshall A. A2 Levi, Marcel A2 Linch, David C. SR Print(0) ID 1178735691 T1 Examination of Blood and Marrow Cells T2 Williams Hematology, 10e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260464122 LK accessmedicine.mhmedical.com/content.aspx?aid=1178735691 RD 2024/03/28 AB SUMMARYExamination of the blood and marrow are mainstays of hematologic diagnosis. The decision to perform a marrow examination, and the types of special studies required, should follow from a careful analysis of blood cells and the history and physical examination of the patient. Currently available automated blood cell analyzers provide an increasing array of novel quantitative parameters and flag abnormal samples that need manual microscopic review. The marrow should be examined when the clinical history, blood cell counts, blood film, or laboratory test results suggest the possibility of a primary or secondary hematologic disorder for which morphologic analysis or special studies of the marrow would aid in the diagnosis. In addition to determining the cellularity and morphology of precursor cells, or infiltration by nonhematopoietic cells, the marrow aspirate and biopsy provide cells for immunophenotyping by flow cytometry or immunostains, cytogenetic and molecular studies, culture of infectious organisms, and storage for further analysis.