RT Book, Section
A1 Beck Jr., Laurence H.
A1 Salant, David J.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1177731287
T1 Acute Interstitial Nephritis
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1177731287
RD 2024/04/24
AB In  1897,  Councilman  reported  on  eight  cases  of  acute  interstitial  nephritis  (AIN)  in  the  Medical  and  Surgical  Reports  of  the  Boston  City  Hospital;  three  as  a  postinfectious  complication  of  scarlet  fever  and  two  from  diphtheria.  Later,  he  described  the  lesion  as  “an  acute  inflammation  of  the  kidney  characterized  by  cellular  and  fluid  exudation  in  the  interstitial  tissue,  accompanied  by,  but  not  dependant  on,  degeneration  of  the  epithelium;  the  exudation  is  not  purulent  in  character,  and  the  lesions  may  be  both  diffuse  and  focal.”  Today  AIN  is  far  more  often  encountered  as  an  allergic  reaction  to  a  drug  (Table  310-1).  Immune-mediated  AIN  may  also  occur  as  part  of  a  known  autoimmune  syndrome,  but  in  some  cases  there  is  no  identifiable  cause  despite  features  suggestive  of  an  immunologic  etiology  (Table  310-1).