RT Book, Section
A1 Hwa, John
A1 Sessa, William C.
A1 Martin, Kathleen
A2 Katzung, Bertram G.
A2 Vanderah, Todd W.
SR Print(0)
ID 1176971579
T1 The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds
T2 Basic & Clinical Pharmacology, 15e
YR 2021
FD 2021
PB McGraw-Hill
PP New York, NY
SN 9781260452310
LK accessmedicine.mhmedical.com/content.aspx?aid=1176971579
RD 2024/04/20
AB CASE  STUDYA  40-year-old  woman  presented  to  her  doctor  with  a  6-month  history  of  increasing  shortness  of  breath*.  This  was  associated  with  poor  appetite  and  ankle  swelling.  On  physical  examination,  she  had  elevated  jugular  venous  distention,  a  soft  tricuspid  regurgitation  murmur,  clear  lungs,  and  mild  peripheral  edema.  An  echocardiogram  revealed  tricuspid  regurgitation,  severely  elevated  pulmonary  pressures,  and  right  ventricular  enlargement.  Cardiac  catheterization  confirmed  the  severely  elevated  pulmonary  pressures.  She  was  commenced  on  appropriate  therapies.  Which  of  the  eicosanoid  agonists  have  been  demonstrated  to  reduce  both  morbidity  and  mortality  in  patients  with  such  a  diagnosis?  What  are  the  modes  of  action?