RT Book, Section
A1 Williams, Saralyn R.
A1 Thurman, R. Jason
A2 Knoop, Kevin J.
A2 Stack, Lawrence B.
A2 Storrow, Alan B.
A2 Thurman, R. Jason
SR Print(0)
ID 1181056948
T1 Anticoagulants
T2 The Atlas of Emergency Medicine, 5e
YR 2021
FD 2021
PB McGraw-Hill
PP New York, NY
SN 9781260134940
LK accessmedicine.mhmedical.com/content.aspx?aid=1181056948
RD 2024/04/18
AB Since  the  discovery  of  the  cause  of  a  hemorrhagic  disorder  in  Wisconsin  cattle  in  the  early  20th  century,  warfarin  and  its  analogs  have  been  used  as  rodenticides  and  pharmacologic  agents.  Warfarin  is  actually  named  after  the  Wisconsin  Alumni  Research  Foundation.  Warfarin-like  xenobiotics  inhibit  the  activity  of  vitamin  K  2,3-epoxide  reductase,  thus  affecting  the  production  of  the  vitamin  K–dependent  factors  of  II,  VII,  IX,  and  X.  While  the  effect  on  the  production  of  the  vitamin  K–dependent  factors  occurs  soon  after  absorption  of  warfarin,  the  clinical  effect  is  delayed  until  the  available  activated  factors  are  depleted.