RT Book, Section A1 Hardin, J. Matthew A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1181043999 T1 Melanoma T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessmedicine.mhmedical.com/content.aspx?aid=1181043999 RD 2024/04/19 AB Melanoma is a potentially fatal cutaneous tumor derived from epidermal melanocytes. Any age can be affected; peak incidence is in 20- to 45-year-old patients (much younger than BCC or SCC). The most significant risk factor is a primary relative with melanoma. Evaluation of any pigmented lesion should include the ABCDE rule (A for asymmetry, B for irregular borders, C for color variegation, D for diameter > 6 mm, and E for elevation and evolving). Any lesion with these characteristics is considered suspicious for melanoma.