RT Book, Section A1 Hardin, J. Matthew A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1181043946 T1 Sweet Syndrome T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessmedicine.mhmedical.com/content.aspx?aid=1181043946 RD 2024/03/29 AB Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is characterized by fever, peripheral neutrophilia, and a nonvasculitic neutrophilic cutaneous eruption. It can occur at any age but most commonly from 30 to 60 years old. Lesions can occur anywhere, but most frequently on the upper extremities, neck, and face; they are typically tender, well-demarcated erythematous plaques with an edematous periphery (pseudovesiculation). Some progress to ulcerations and hemorrhagic crusting. Variants have been isolated to the face (erysipelas-like) and the dorsal hands. The plaques generally cause a burning pain and are nonpruritic. Sweet syndrome is associated with preceding upper respiratory infections, vaccinations, medications, malignancies, inflammatory bowel disease, autoimmune connective tissue diseases, and pregnancy.