RT Book, Section
A1 Hardin, J. Matthew
A2 Knoop, Kevin J.
A2 Stack, Lawrence B.
A2 Storrow, Alan B.
A2 Thurman, R. Jason
SR Print(0)
ID 1181043780
T1 Fixed Drug Eruption
T2 The Atlas of Emergency Medicine, 5e
YR 2021
FD 2021
PB McGraw-Hill
PP New York, NY
SN 9781260134940
LK accessmedicine.mhmedical.com/content.aspx?aid=1181043780
RD 2024/04/17
AB Fixed  drug  eruptions  (FDEs)  appear  3  to  14  days  after  1st  exposure.  The  lesions  can  appear  anywhere,  including  mucous  membranes,  but  are  most  common  on  the  face,  lips,  hands,  feet,  and  genitalia.  Single  or  multiple  annular,  edematous,  well-demarcated  plaques  are  typical.  A  central  vesicle,  bulla,  or  erosion  may  occur.  After  stopping  the  offending  medication,  the  lesion(s)  fade  over  several  days  to  weeks.  Residual  hyperpigmentation  is  common.  Within  24  hours  of  reexposure  to  the  culprit  medication,  the  exact  rash  reappears.  The  most  common  offending  medications  are  sulfonamides,  NSAIDs,  barbiturates,  tetracyclines,  and  carbamazepine.