RT Book, Section A1 Shah, Ashish A1 Sobolewski, Brad A1 Mittiga, Matthew R. A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1181044397 T1 Cold Panniculitis (Popsicle Panniculitis) T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessmedicine.mhmedical.com/content.aspx?aid=1181044397 RD 2024/03/29 AB Cold panniculitis represents acute cold injury resulting in inflammation of the subcutaneous fat. It manifests as erythematous, indurated nodules, and plaques on exposed skin, especially the perioral areas and cheeks. Lesions appear 24 to 72 hours after exposure to cold and gradually soften and return to normal over 1 to 2 weeks usually without permanent sequelae. This phenomenon is caused by subcutaneous fat solidification and necrosis following exposure to cold temperatures. It is much more common in infants. The differential diagnosis includes facial cellulitis, frostbite, trauma, pressure erythema, giant urticaria, and contact dermatitis.