RT Book, Section
A1 Levinson, Warren
A1 Chin-Hong, Peter
A1 Joyce, Elizabeth A.
A1 Nussbaum, Jesse
A1 Schwartz, Brian
SR Print(0)
ID 1175830224
T1 Slow Viruses & Prions
T2 Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 16e
YR 2020
FD 2020
PB McGraw Hill
PP New York, NY
SN 9781260116717
LK accessmedicine.mhmedical.com/content.aspx?aid=1175830224
RD 2024/04/19
AB “Slow”  infectious  diseases  are  caused  by  a  heterogeneous  group  of  agents  containing  both  conventional  viruses  and  unconventional  agents  that  are  not  viruses  (e.g.,  prions).  Prions  are  protein-containing  particles  with  no  detectable  nucleic  acid  that  are  highly  resistant  to  inactivation  by  heat,  formaldehyde,  and  ultraviolet  light  at  doses  that  will  inactivate  viruses.  Note  that  prions  are  resistant  to  the  temperatures  usually  employed  in  cooking,  a  fact  that  may  be  important  in  their  suspected  ability  to  be  transmitted  by  food  (see  variant  Creutzfeldt-Jakob  disease  [vCJD]  later).  Prions  are,  however,  inactivated  by  protein-  and  lipid-disrupting  agents  such  as  phenol,  ether,  NaOH,  and  hypochlorite  (see  Chapter  28).