RT Book, Section
A1 Levinson, Warren
A1 Chin-Hong, Peter
A1 Joyce, Elizabeth A.
A1 Nussbaum, Jesse
A1 Schwartz, Brian
SR Print(0)
ID 1175827295
T1 Tolerance & Autoimmune Disease
T2 Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 16e
YR 2020
FD 2020
PB McGraw Hill
PP New York, NY
SN 9781260116717
LK accessmedicine.mhmedical.com/content.aspx?aid=1175827295
RD 2024/04/16
AB Immune  tolerance  is  the  lack  of  responsiveness  to  a  specific  antigen  that  could  otherwise  elicit  an  immune  response.  The  best  example  of  antigen  tolerance  is  a  host’s  normal  absence  of  response  for  “self”  antigens,  while  those  same  antigens  might  be  considered  “foreign”  if  transplanted  to  a  different  host.  Because  it  applies  to  responses  to  antigens,  tolerance  is  a  feature  of  adaptive  immunity,  although  certain  antigen-presenting  cells  can  have  a  tolerogenic  effect  on  T  cells.  In  this  chapter,  we  will  discuss  how  immune  tolerance  to  “self”  develops  and  what  happens  when  that  tolerance  is  broken.