RT Book, Section
A1 Levinson, Warren
A1 Chin-Hong, Peter
A1 Joyce, Elizabeth A.
A1 Nussbaum, Jesse
A1 Schwartz, Brian
SR Print(0)
ID 1175827037
T1 Major Histocompatibility Complex & Transplantation
T2 Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 16e
YR 2020
FD 2020
PB McGraw Hill
PP New York, NY
SN 9781260116717
LK accessmedicine.mhmedical.com/content.aspx?aid=1175827037
RD 2024/04/25
AB The  success  of  tissue  and  organ  transplants  depends  on  the  donor’s  and  recipient’s  major  histocompatibility  complex  (MHC)  proteins,  which  present  antigens  to  T  cells.  The  MHC  proteins  are  alloantigens  (i.e.,  they  differ  among  members  of  the  same  species).  In  humans,  these  proteins  are  encoded  by  the  human  leukocyte  antigen  (HLA)  genes,  clustered  on  chromosome  6.  (Note  that  we  will  use  MHC  and  HLA  interchangeably.)  Three  of  these  genes  (HLA-A,  HLA-B,  and  HLA-C)  code  for  the  class  I  MHC  proteins.  Several  HLA-D  loci  determine  the  class  II  MHC  proteins  (i.e.,  DP,  DQ,  and  DR)  (Figure  62–1).  The  features  of  class  I  and  class  II  MHC  proteins  are  compared  in  Table  62–1.  If  the  HLA  proteins  on  the  donor’s  cells  differ  from  those  on  the  recipient’s  cells,  then  an  immune  response  occurs  in  the  recipient.