RT Book, Section
A1 Bunn, H. Franklin
A1 Sankaran, Vijay G.
A2 Aster, Jon C.
A2 Bunn, H. Franklin
SR Print(0)
ID 1175524796
T1 Thalassemia
T2 Pathophysiology of Blood Disorders, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9781259642067
LK accessmedicine.mhmedical.com/content.aspx?aid=1175524796
RD 2024/04/18
AB LEARNING  OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Outline  the  changes  in  globin  gene  expression  that  occur  during  fetal  development.Explain  the  molecular  genetics  and  inheritance  of  alpha  (α)-  and  beta  (β)-thalassemias.Grasp  the  cellular  pathogenesis  of  α-  and  β-thalassemias.Describe  the  clinical  and  laboratory  features  of  β-thalassemia  minor  (trait)  and  β-thalassemia  major  and  the  different  types  of  α-thalassemia.Understand  the  pathophysiologic  principles  underlying  treatment  of  β-thalassemia  major.