RT Book, Section
A1 Dirkx, Tonja C.
A1 Woodell, Tyler B.
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
SR Print(0)
ID 1177463038
T1 Gout & The Kidney
T2 Current Medical Diagnosis & Treatment 2021
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260469868
LK accessmedicine.mhmedical.com/content.aspx?aid=1177463038
RD 2023/02/06
AB The  kidney  is  the  primary  organ  for  excretion  of  uric  acid.  Patients  with  proximal  tubular  dysfunction  have  decreased  excretion  of  uric  acid  and  are  more  prone  to  gouty  arthritis  attacks.  Depending  on  the  pH  and  uric  acid  concentration,  deposition  can  occur  in  the  tubules,  the  interstitium,  or  the  urinary  tract.  The  more  alkaline  pH  of  the  interstitium  causes  urate  salt  deposition,  whereas  the  acidic  environment  of  the  tubules  and  urinary  tract  causes  uric  acid  crystal  deposition  at  high  concentrations.