RT Book, Section
A1 Dirkx, Tonja C.
A1 Woodell, Tyler B.
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
SR Print(0)
ID 1177463013
T1 Medullary Sponge Kidney
T2 Current Medical Diagnosis & Treatment 2021
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260469868
LK accessmedicine.mhmedical.com/content.aspx?aid=1177463013
RD 2023/02/05
AB This  disease  is  a  relatively  common  and  benign  disorder  that  is  present  at  birth  and  not  usually  diagnosed  until  the  fourth  or  fifth  decade.  It  can  be  caused  by  autosomal  dominant  mutations  in  the  MCKD1  or  MCKD2  genes  on  chromosomes  1  and  16,  respectively.  Kidneys  have  a  marked  irregular  enlargement  of  the  medullary  and  interpapillary  collecting  ducts.  This  is  associated  with  medullary  cysts  that  are  diffuse,  giving  a  “Swiss  cheese”  appearance  in  these  regions.