RT Book, Section
A1 Chesnutt, Asha N.
A1 Chesnutt, Mark S.
A1 Prendergast, Niall T.
A1 Prendergast, Thomas J.
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
SR Print(0)
ID 1175807975
T1 Pulmonary Vasculitis
T2 Current Medical Diagnosis & Treatment 2021
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260469868
LK accessmedicine.mhmedical.com/content.aspx?aid=1175807975
RD 2023/03/31
AB Granulomatosis  with  polyangiitis  is  an  idiopathic  disease  manifested  by  a  combination  of  glomerulonephritis,  necrotizing  granulomatous  vasculitis  of  the  upper  and  lower  respiratory  tracts,  and  varying  degrees  of  small-vessel  vasculitis.  Chronic  sinusitis,  arthralgias,  fever,  skin  rash,  and  weight  loss  are  frequent  presenting  symptoms.  Specific  pulmonary  complaints  occur  less  often.  The  most  common  sign  of  lung  disease  is  nodular  pulmonary  infiltrates,  often  with  cavitation,  seen  on  chest  radiography.  Tracheal  stenosis  and  endobronchial  disease  are  sometimes  seen.  The  diagnosis  is  most  often  based  on  serologic  testing  and  biopsy  of  lung,  sinus  tissue,  or  kidney  with  demonstration  of  necrotizing  granulomatous  vasculitis  (Chapter  20).