RT Book, Section
A1 Geller, Richard J.
A2 Olson, Kent R.
A2 Anderson, Ilene B.
A2 Benowitz, Neal L.
A2 Blanc, Paul D.
A2 Clark, Richard F.
A2 Kearney, Thomas E.
A2 Kim-Katz, Susan Y.
A2 Wu, Alan H. B.
SR Print(0)
ID 1174605803
T1 DISULFIRAM
T2 Poisoning & Drug Overdose, 7e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071839792
LK accessmedicine.mhmedical.com/content.aspx?aid=1174605803
RD 2024/04/24
AB Disulfiram  (tetraethylthiuram  disulfide  [CASRN  97-77-8],  or  Antabuse)  is  an  antioxidant  industrial  chemical  produced  since  1881  for  the  vulcanization  of  rubber.  Introduced  in  the  1930s  into  clinical  medicine  as  a  vermicide  and  scabicide,  it  has  been  used  in  the  United  States  since  1951  as  a  drug  in  the  treatment  of  alcoholism.  Ingestion  of  ethanol  while  taking  disulfiram  causes  a  well-defined  unpleasant  reaction,  the  fear  of  which  provides  a  negative  incentive  to  drink  alcohol.  Clinical  toxicity  is  caused  by  overdose  or  occurs  as  a  result  of  a  disulfiram–ethanol  drug  interaction.  Disulfiram  is  being  investigated  for  the  treatment  of  cocaine  addiction,  drug-resistant  fungal  infections,  and  malignancies.  The  toxicities  resulting  from  disulfiram  overdose  differ  from  those  of  disulfiram–ethanol  interaction.