RT Book, Section
A1 Sutter, Mark
A2 Olson, Kent R.
A2 Anderson, Ilene B.
A2 Benowitz, Neal L.
A2 Blanc, Paul D.
A2 Clark, Richard F.
A2 Kearney, Thomas E.
A2 Kim-Katz, Susan Y.
A2 Wu, Alan H. B.
SR Print(0)
ID 1174605665
T1 COLCHICINE
T2 Poisoning & Drug Overdose, 7e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071839792
LK accessmedicine.mhmedical.com/content.aspx?aid=1174605665
RD 2024/10/13
AB Colchicine  is  FDA  approved  for  the  treatment  and  prophylaxis  of  gout  and  familial  Mediterranean  fever.  It  is  also  used  for  acute  and  recurrent  pericarditis  and  a  variety  of  inflammatory  conditions  such  as  Behçet  disease.  It  is  available  in  tablet  form,  and  it  is  also  found  in  certain  plants,  such  as  Colchicum  autumnale  (autumn  crocus  or  meadow  saffron)  and  Gloriosa  superba  (glory  lily).  The  injectable  form  of  colchicine  was  banned  in  2009  by  the  FDA  due  to  serious  toxicity.  Its  antimitotic  mechanism  of  action  is  similar  to  that  of  some  chemotherapeutic  agents,  and  colchicine  overdoses  are  extremely  serious,  with  considerable  mortality.