RT Book, Section
A1 Arens, Ann
A2 Olson, Kent R.
A2 Anderson, Ilene B.
A2 Benowitz, Neal L.
A2 Blanc, Paul D.
A2 Clark, Richard F.
A2 Kearney, Thomas E.
A2 Kim-Katz, Susan Y.
A2 Wu, Alan H. B.
SR Print(0)
ID 1174604874
T1 AMANTADINE
T2 Poisoning & Drug Overdose, 7e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071839792
LK accessmedicine.mhmedical.com/content.aspx?aid=1174604874
RD 2024/04/25
AB Amantadine  (Symmetrel)  is  an  antiviral  agent  whose  dopaminergic  properties  make  it  effective  in  the  treatment  of  Parkinson's  disease  and  for  prophylaxis  against  the  parkinsonian  side  effects  of  neuroleptic  agents.  Although  amantadine  is  no  longer  recommended  for  the  treatment  or  prophylaxis  of  influenza  because  of  resistance,  it  has  been  studied  as  a  potential  treatment  for  hepatitis  C,  Huntington's  disease,  brain  injury  or  encephalopathy,  and  cocaine  dependence.  Its  effects  in  acute  overdose  have  been  associated  with  seizures,  arrhythmias,  and  death.  Withdrawal  from  amantadine  has  also  been  linked  to  neuroleptic  malignant  syndrome.