RT Book, Section
A1 Bartz, Sarah
A1 Chambers, Christina
A1 Chan, Christine M.
A1 Cree-Green, Melanie
A1 Davis, Shanlee
A1 Hsu, Stephanie
A2 Hay Jr., William W.
A2 Levin, Myron J.
A2 Abzug, Mark J.
A2 Bunik, Maya
SR Print(0)
ID 1172111615
T1 Endocrine Disorders
T2 Current Diagnosis & Treatment: Pediatrics, 25e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260457827
LK accessmedicine.mhmedical.com/content.aspx?aid=1172111615
RD 2024/04/19
AB The  classic  concept  that  endocrine  effects  are  the  result  of  substances  secreted  into  the  blood  with  effects  on  a  distant  target  cell  has  been  updated  to  account  for  other  ways  in  which  hormonal  effects  occur.  Specifically,  some  hormone  systems  involve  the  stimulation  or  inhibition  of  metabolic  processes  in  neighboring  cells  (eg,  within  the  pancreatic  islets  or  cartilage).  This  phenomenon  is  termed  paracrine.  Other  hormone  effects  reflect  the  action  of  hormones  on  the  same  cells  that  produced  them.  This  action  is  termed  autocrine.  The  discoveries  of  local  production  of  ghrelin,  somatostatin,  cholecystokinin,  incretins,  and  many  other  hormones  in  the  brain  and  gut  support  the  concept  of  paracrine  and  autocrine  processes  in  these  tissues.