RT Book, Section A1 Baskin, Laurence S. A2 McAninch, Jack W. A2 Lue, Tom F. SR Print(0) ID 1171186744 T1 Disorders of Sex Development T2 Smith & Tanagho's General Urology, 19e YR 2020 FD 2020 PB McGraw Hill PP New York, NY SN 9781259834332 LK accessmedicine.mhmedical.com/content.aspx?aid=1171186744 RD 2024/03/29 AB What defines our sexuality is a complex interaction between our genetic makeup, environmental stimulus, and cultural influences. The origins of our sexuality occur at the time of conception when the genetic material from two sources of the opposite sex coalesces into a new individual. From that moment, sexual differentiation occurs by a highly organized process. Sex chromosomes and autosomes dictate the development of gonads; the gonads, in turn, produce hormones, which then direct the development of the internal and external genitalia. Disorders of sex development (DSD) or differentiation arise from abnormalities in chromosomes, gonadal development, or hormonal production/activity.