RT Book, Section
A1 Dunphy, Cherie H.
A1 Fedoriw, Yuri
A1 Mathews, Stephanie P.
A1 Perjar, Irina
A2 Reisner, Howard M.
SR Print(0)
ID 1173780915
T1 Hematopathology
T2 Pathology: A Modern Case Study, 2e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN REISNERPATHOL
LK accessmedicine.mhmedical.com/content.aspx?aid=1173780915
RD 2024/04/23
AB WHAT  WE  DOHematopathology  is  one  of  the  most  diverse  areas  of  pathology,  since  it  represents  a  hybrid  discipline  involving  clinical  pathology  (i.e.,  laboratory  medicine)  and  anatomic  pathology  (surgical  pathology  of  lymph  nodes  and  extranodal  tissues  involved  by  hematolymphoid  disorders).  This  field  of  pathology  also  uses  cytomorphology  and  histology  in  combination  with  numerous  ancillary  tools  (i.e.,  enzyme  cytochemical  and  immunohistochemical  staining,  flow  cytometric  immunophenotyping,  and  cytogenetic  and  molecular  techniques)  in  diagnosing  and  prognosticating  hematolymphoid  disorders.  In  some  instances,  the  appropriate  diagnosis  of  the  hematolymphoid  disorder  also  relies  heavily  on  clinical  and  radiologic  data.For  example,  acute  promyelocytic  leukemia  (APL)  (as  described  later  in  this  chapter)  has  characteristic  cytomorphological,  enzyme  cytochemical,  and  flow  cytometric  immunophenotypic  features  that  are  defined  by  the  ever-present  t(15;17)(q24;21)  or  similar  chromosomal  variant.  This  translocation  may  be  detected  most  rapidly  by  fluorescence  in  situ  hybridization  (FISH)  performed  in  the  cytogenetics  laboratory.  It  is  important  to  recognize  this  subtype  of  acute  myeloid  leukemia  (AML)  as  soon  as  possible,  since  it  is  often  associated  with  disseminated  intravascular  coagulation  (DIC)  and  has  a  specific  therapy  (different  from  all  other  forms  of  AML).As  an  additional  example,  evaluation  of  plasma  cell  proliferations  relies  heavily  on  cytomorphological  and  histological  features  in  combination  with  immunohistochemical  and  in  situ  hybridization  studies  for  clonality.  However,  even  with  these  techniques,  the  appropriate  classification  (and  prognostication)  of  the  plasma  cell  neoplasm  (PCN)  must  be  based  on  close  integration  of  the  clinical,  radiologic,  and  cytogenetic  data  in  each  case,  as  described  again  later  in  this  chapter.