RT Book, Section
A1 Ramkissoon, Lori A.
A1 Montgomery, Nathan D.
A2 Reisner, Howard M.
SR Print(0)
ID 1173767392
T1 Cancer and the Genome
T2 Pathology: A Modern Case Study, 2e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN REISNERPATHOL
LK accessmedicine.mhmedical.com/content.aspx?aid=1173767392
RD 2020/08/13
AB Each  year,  there  are  an  estimated  18  million  new  cancers  diagnosed  worldwide  with  more  than  9  million  people  succumbing  to  the  disease.1  In  the  most  basic  terms,  cancer  is  simply  uncontrolled  cell  growth.  However,  the  reality  is  that  cancer  represents  a  highly  complex,  dynamic  process  that  manipulates  normal  cellular  processes  in  order  to  maintain  growth  and  survival  advantages  that  are  not  subject  to  traditional  regulation.  Although  cancer  arises  through  multiple  different  mechanisms  and  manifests  in  a  variety  of  forms,  fundamentally  it  represents  a  disease  of  genetic  alterations  that  result  in  characteristic  histologic,  radiologic,  and  clinical  findings.  In  this  chapter,  we  will  discuss  the  role  and  impact  of  genomic  alterations  in  cancer.  However,  before  we  can  understand  how  genomes  go  awry  in  cancer,  we  must  first  review  basic  features  of  “normal”  human  genomes.  The  next  section  provides  an  introduction  to  genes  and  their  expression.  Those  with  an  advanced  background  in  genetics  and  molecular  biology  may  be  comfortable  skipping  ahead  to  “Mutations  and  Cancer.”