RT Book, Section
A1 Jameson, J. Larry
A1 Fauci, Anthony S.
A1 Kasper, Dennis L.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Loscalzo, Joseph
SR Print(0)
ID 1167065029
T1 Pneumocystis Pneumonia, Candidiasis, and Other Fungal Infections
T2 Harrison's Manual of Medicine, 20e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260455342
LK accessmedicine.mhmedical.com/content.aspx?aid=1167065029
RD 2024/04/23
AB Yeasts  (e.g.,  Candida,  Cryptococcus)  appear  microscopically  as  round,  budding  forms;  molds  (e.g.,  Aspergillus,  Rhizopus)  appear  as  filamentous  forms  called  hyphae;  and  dimorphic  fungi  (e.g.,  Histoplasma)  are  spherical  in  tissue  but  appear  as  molds  in  the  environment.–  Endemic  fungi  (e.g.,  Coccidioides)  are  not  part  of  the  normal  human  microbiota  and  infect  hosts  preferentially  by  inhalation.–  Opportunistic  fungi  (e.g.,  Candida  and  Aspergillus)  invade  the  host  from  normal  sites  of  colonization  (e.g.,  mucous  membranes  or  the  GI  tract).Definitive  diagnosis  of  any  fungal  infection  requires  histopathologic  identification  of  the  fungus  invading  tissue  and  accompanying  evidence  of  an  inflammatory  response.–  Other  tests  that  detect  antigens  (e.g.,  for  Histoplasma,  Cryptococcus,  Aspergillus)  or  antibody  (e.g.,  for  Coccidioides)  have  different  degrees  of  specificity  and  sensitivity.