RT Book, Section
A1 Jameson, J. Larry
A1 Fauci, Anthony S.
A1 Kasper, Dennis L.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Loscalzo, Joseph
SR Print(0)
ID 1167069034
T1 ALS and Other Motor Neuron Diseases
T2 Harrison's Manual of Medicine, 20e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260455342
LK accessmedicine.mhmedical.com/content.aspx?aid=1167069034
RD 2024/04/24
AB Amyotrophic  lateral  sclerosis  (ALS)  is  the  most  common  form  of  progressive  motor  neuron  disease  (Table  188-1).  ALS  is  caused  by  degeneration  of  motor  neurons  at  all  levels  of  the  CNS,  including  anterior  horns  of  the  spinal  cord,  brainstem  motor  nuclei,  and  motor  cortex.  Familial  ALS  (FALS)  represents  5–10%  of  the  total  and  is  inherited  usually  as  an  autosomal  dominant  disorder.