RT Book, Section
A1 Jameson, J. Larry
A1 Fauci, Anthony S.
A1 Kasper, Dennis L.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Loscalzo, Joseph
SR Print(0)
ID 1167068441
T1 Other Musculoskeletal Disorders
T2 Harrison's Manual of Medicine, 20e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260455342
LK accessmedicine.mhmedical.com/content.aspx?aid=1167068441
RD 2024/04/25
AB An  idiopathic  disorder  characterized  by  recurrent  inflammation  of  cartilaginous  structures.  Cardinal  manifestations  include  ear  and  nose  involvement  with  floppy  ear  and  saddlenose  deformities,  inflammation  and  collapse  of  tracheal  and  bronchial  cartilaginous  rings,  and  asymmetric  episodic  nondeforming  polyarthritis.  Other  features  can  include  scleritis,  conjunctivitis,  iritis,  keratitis,  aortic  regurgitation,  glomerulonephritis,  and  other  features  of  systemic  vasculitis.  Onset  is  frequently  abrupt,  with  the  appearance  of  1–2  sites  of  cartilaginous  inflammation.  Diagnosis  is  made  clinically  and  may  be  confirmed  by  biopsy  of  affected  cartilage.