RT Book, Section
A1 Jameson, J. Larry
A1 Fauci, Anthony S.
A1 Kasper, Dennis L.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Loscalzo, Joseph
SR Print(0)
ID 1167068167
T1 Primary Immune Deficiency Diseases
T2 Harrison's Manual of Medicine, 20e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260455342
LK accessmedicine.mhmedical.com/content.aspx?aid=1167068167
RD 2024/04/19
AB Primary  immunodeficiencies  are  genetic  diseases  that  can  involve  all  possible  aspects  of  immune  responses,  from  innate  through  adaptive,  as  well  as  cell  differentiation,  effector  function,  and  immune  regulation  (Table  160-1).  The  consequences  of  primary  immunodeficiencies  vary  widely  as  a  function  of  the  molecules  that  are  defective  and  include  vulnerability  to  infection  by  pathogenic  and  opportunistic  infection,  immunopathologic  responses  such  as  allergy,  lymphoproliferations,  and  autoimmunity,  and  increased  risk  of  cancers.  The  locations  and  sites  of  infection  and  the  causal  microorganisms  often  aid  the  physician  in  diagnosis.