RT Book, Section A1 Jameson, J. Larry A1 Fauci, Anthony S. A1 Kasper, Dennis L. A1 Hauser, Stephen L. A1 Longo, Dan L. A1 Loscalzo, Joseph SR Print(0) ID 1167067907 T1 Pancreatitis T2 Harrison's Manual of Medicine, 20e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781260455342 LK accessmedicine.mhmedical.com/content.aspx?aid=1167067907 RD 2024/04/19 AB Any severe acute pain in the abdomen or back should suggest the possibility of acute pancreatitis. The diagnosis is established by two of the following three criteria: (1) typical abdominal pain in the epigastrium that may radiate to the back, (2) threefold or greater elevation in serum lipase and/or amylase, and (3) confirmatory findings of acute pancreatitis on cross-sectional abdominal imaging. Pathologically, acute pancreatitis varies from interstitial pancreatitis, which is usually a mild and self-limited disorder, to necrotizing pancreatitis, in which the degree of necrosis may correlate with the severity of the attack and its systemic manifestations.