RT Book, Section
A1 Jameson, J. Larry
A1 Fauci, Anthony S.
A1 Kasper, Dennis L.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Loscalzo, Joseph
SR Print(0)
ID 1167067707
T1 Peptic Ulcer and Related Disorders
T2 Harrison's Manual of Medicine, 20e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260455342
LK accessmedicine.mhmedical.com/content.aspx?aid=1167067707
RD 2024/04/24
AB Peptic  ulcer  disease  (PUD)  occurs  most  commonly  in  duodenal  bulb  (duodenal  ulcer,  DU)  and  stomach  (gastric  ulcer,  GU).  It  may  also  occur  in  esophagus,  pyloric  channel,  duodenal  loop,  jejunum,  and  Meckel’s  diverticulum.  PUD  results  when  “aggressive”  factors  (gastric  acid,  pepsin)  overwhelm  “defensive”  factors  involved  in  mucosal  resistance  (gastric  mucus,  bicarbonate,  microcirculation,  prostaglandins,  mucosal  “barrier”)  and  from  effects  of  Helicobacter  pylori.