RT Book, Section
A1 Jameson, J. Larry
A1 Fauci, Anthony S.
A1 Kasper, Dennis L.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Loscalzo, Joseph
SR Print(0)
ID 1167067527
T1 Glomerular Diseases
T2 Harrison's Manual of Medicine, 20e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260455342
LK accessmedicine.mhmedical.com/content.aspx?aid=1167067527
RD 2024/04/18
AB Historically  called  the  “nephritic  syndrome.”  Characterized  by  development,  over  days,  of  azotemia,  hypertension,  edema,  hematuria,  proteinuria,  and  sometimes  oliguria.  Salt  and  water  retention  are  due  to  reduced  glomerular  filtration  rate  (GFR)  and  may  result  in  circulatory  congestion.  Red  blood  cell  (RBC)  casts  on  urinalysis  confirm  diagnosis.  Proteinuria  is  usually  <3  g/d.  Most  forms  of  acute  GN  are  mediated  by  humoral  immune  mechanisms.  Clinical  course  depends  on  underlying  lesion  (Table  145-1).