RT Book, Section A1 Jameson, J. Larry A1 Fauci, Anthony S. A1 Kasper, Dennis L. A1 Hauser, Stephen L. A1 Longo, Dan L. A1 Loscalzo, Joseph SR Print(0) ID 1167067469 T1 Renal Transplantation T2 Harrison's Manual of Medicine, 20e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781260455342 LK accessmedicine.mhmedical.com/content.aspx?aid=1167067469 RD 2024/03/29 AB With the advent of more potent and well-tolerated immunosuppressive regimens and further improvements in short-term graft survival, renal transplantation remains the treatment of choice for most pts with end-stage renal disease. Results are best with living-related transplantation, in part because of optimized tissue matching and in part because waiting time and ischemic time can be minimized; ideally, these pts are transplanted prior to the onset of symptomatic uremia or indications for dialysis. Transplant centers now also perform living-unrelated donor (e.g., spousal) transplants, often in “chains” involving multiple donors to optimize tissue matching. Graft survival in these cases is far superior to that observed with deceased donor transplants, although less favorable than with living-related transplants.