RT Book, Section
A1 Jameson, J. Larry
A1 Fauci, Anthony S.
A1 Kasper, Dennis L.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Loscalzo, Joseph
SR Print(0)
ID 1167067438
T1 Chronic Kidney Disease and Uremia
T2 Harrison's Manual of Medicine, 20e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260455342
LK accessmedicine.mhmedical.com/content.aspx?aid=1167067438
RD 2024/04/23
AB The  prevalence  of  chronic  kidney  disease  (CKD),  generally  defined  as  a  long-standing,  irreversible  impairment  of  kidney  function,  is  substantially  greater  than  the  number  of  pts  with  end-stage  renal  disease  (ESRD),  now  ≥500,000  in  the  United  States.  There  is  a  spectrum  of  disease  related  to  decrements  in  renal  function;  clinical  and  therapeutic  issues  differ  greatly  depending  on  whether  the  glomerular  filtration  rate  (GFR)  reduction  is  moderate  (stage  3  CKD,  30–59  mL/min  per  1.73  m2)  (see  Table  48-1),  severe  (stage  4  CKD,  15–29  mL/min  per  1.73  m2),  or  “end-stage  renal  disease”  (stage  5  CKD,  <15  mL/min  per  1.73  m2).  Dialysis  is  usually  required  once  GFR  <10  mL/min  per  1.73  m2.  Common  causes  of  CKD  are  outlined  in  Table  142-1.