RT Book, Section
A1 Jameson, J. Larry
A1 Fauci, Anthony S.
A1 Kasper, Dennis L.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Loscalzo, Joseph
SR Print(0)
ID 1167067360
T1 Interstitial Lung Disease
T2 Harrison's Manual of Medicine, 20e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260455342
LK accessmedicine.mhmedical.com/content.aspx?aid=1167067360
RD 2024/04/24
AB Interstitial  lung  diseases  (ILDs)  are  a  group  of  >200  disease  entities  characterized  by  diffuse  lung  parenchymal  abnormalities.  ILDs  can  be  classified  into  two  major  groups:  (1)  diseases  associated  with  predominant  inflammation  and  fibrosis,  and  (2)  diseases  with  predominantly  granulomatous  reaction  in  interstitial  or  vascular  areas  (Table  136-1).  ILDs  are  nonmalignant  and  noninfectious,  and  they  are  typically  chronic.  The  differential  diagnosis  of  ILDs  often  includes  infections  (e.g.,  atypical  mycobacteria,  fungi),  congestive  heart  failure,  and  malignancy  (e.g.,  bronchoalveolar  cell  carcinoma).  One  of  the  most  common  ILDs  associated  with  a  granulomatous  reaction,  sarcoidosis,  is  discussed  in  Chap.  169.  Other  common  ILDs  include  idiopathic  pulmonary  fibrosis  (IPF)  and  ILDs  related  to  connective  tissue  diseases.  Many  ILDs  are  of  unknown  etiology;  however,  some  ILDs  are  known  to  be  associated  with  specific  environmental  exposures  including  asbestos,  radiation  therapy,  and  organic  dusts.