RT Book, Section
A1 Jameson, J. Larry
A1 Fauci, Anthony S.
A1 Kasper, Dennis L.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Loscalzo, Joseph
SR Print(0)
ID 1167064473
T1 Neurologic Paraneoplastic Syndromes
T2 Harrison's Manual of Medicine, 20e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260455342
LK accessmedicine.mhmedical.com/content.aspx?aid=1167064473
RD 2024/04/24
AB Paraneoplastic  neurologic  disorders  (PNDs)  are  cancer-related  syndromes  that  can  affect  any  part  of  the  nervous  system;  caused  by  mechanisms  other  than  metastasis  or  by  complications  of  cancer  such  as  coagulopathy,  stroke,  metabolic  and  nutritional  conditions,  infections,  and  side  effects  of  cancer  therapy.  In  60%  of  pts  the  neurologic  symptoms  precede  cancer  diagnosis.  PNDs  occur  in  0.5–1%  of  all  cancer  pts,  but  they  occur  in  2–3%  of  pts  with  neuroblastoma  or  small  cell  lung  cancer  (SCLC),  and  in  30–50%  of  pts  with  thymoma  or  sclerotic  myeloma.