RT Book, Section
A1 Jameson, J. Larry
A1 Fauci, Anthony S.
A1 Kasper, Dennis L.
A1 Hauser, Stephen L.
A1 Longo, Dan L.
A1 Loscalzo, Joseph
SR Print(0)
ID 1167062710
T1 Increased Intracranial Pressure and Head Trauma
T2 Harrison's Manual of Medicine, 20e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260455342
LK accessmedicine.mhmedical.com/content.aspx?aid=1167062710
RD 2023/05/30
AB A  limited  volume  of  extra  tissue,  blood,  CSF,  or  edema  can  be  added  to  the  intracranial  contents  without  raising  the  intracranial  pressure  (ICP).  Clinical  deterioration  or  death  may  follow  increases  in  ICP  that  shift  intracranial  contents,  distort  vital  brainstem  centers,  or  compromise  cerebral  perfusion.  Cerebral  perfusion  pressure  (CPP),  defined  as  the  mean  arterial  pressure  (MAP)  minus  the  ICP,  is  the  driving  force  for  circulation  across  capillary  beds  of  the  brain;  decreased  CPP  is  a  fundamental  mechanism  of  secondary  ischemic  brain  injury  and  constitutes  an  emergency  that  requires  immediate  attention.  In  general,  ICP  should  be  maintained  at  <20  mmHg  and  CPP  should  be  maintained  at  ≥60  mmHg.