RT Book, Section A1 Raj, Kristin S. A1 Williams, Nolan A1 DeBattista, Charles A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. SR Print(0) ID 1166172914 T1 Other Drug & Substance Use Disorders T2 Current Medical Diagnosis and Treatment 2020 YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781260455281 LK accessmedicine.mhmedical.com/content.aspx?aid=1166172914 RD 2022/05/24 AB While the terms “opioids” and “narcotics” both refer to a group of drugs with actions that mimic those of morphine, the term “opioids” is used when discussing medications prescribed in a controlled manner by a clinician, and the term “narcotics” is used to connote illicit drug use. The group includes natural derivatives of opium (opiates), synthetic surrogates (opioids), and a number of polypeptides, some of which have been discovered to be natural neurotransmitters. The principal narcotic of abuse is heroin (metabolized to morphine), which is not used as a legitimate medication. Heroin has taken a more widespread geographic distribution, involving primarily white men and women in their late 20s living outside of large urban areas. The other common opioids are prescription medications that differ in milligram potency, duration of action, and agonist and antagonist capabilities (see Chapter 5-11). All of the opioid analgesics can be reversed by the opioid antagonist naloxone.