RT Book, Section A1 Smollin, Craig A1 Olson, Kent R. A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. SR Print(0) ID 1166176152 T1 Poisoning or Overdose-Related Hyperthermia T2 Current Medical Diagnosis and Treatment 2020 YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781260455281 LK accessmedicine.mhmedical.com/content.aspx?aid=1166176152 RD 2022/05/23 AB Hyperthermia may be associated with poisoning by amphetamines and other synthetic stimulants (cathinones, piperazines), atropine and other anticholinergic drugs, cocaine, salicylates, strychnine, tricyclic antidepressants, and various other medications. Overdoses of serotonin reuptake inhibitors (eg, fluoxetine, paroxetine, sertraline) or their use in a patient taking an MAO inhibitor may cause agitation, hyperactivity, myoclonus, and hyperthermia (“serotonin syndrome”). Antipsychotic agents can cause rigidity and hyperthermia (neuroleptic malignant syndrome [NMS]). (See section on schizophrenia and other psychotic disorders in Chapter 25-11.) Malignant hyperthermia is a rare disorder associated with general anesthetic agents.