RT Book, Section
A1 Wightman, Rachel S.
A1 Perrone, Jeanmarie
A2 Tintinalli, Judith E.
A2 Ma, O. John
A2 Yealy, Donald M.
A2 Meckler, Garth D.
A2 Stapczynski, J. Stephan
A2 Cline, David M.
A2 Thomas, Stephen H.
SR Print(0)
ID 1166600319
T1 Cocaine and Amphetamines
T2 Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260019933
LK accessmedicine.mhmedical.com/content.aspx?aid=1166600319
RD 2024/04/18
AB Historical  records  of  indigenous  cultures  in  South  America  describe  early  stimulant  use  by  chewing  leaves  of  the  Erythroxylum  coca  plant,  a  practice  that  continues  today.  Cocaine  was  first  used  therapeutically  in  1884  for  ophthalmologic  procedures,  accompanied  closely  by  reports  of  severe  toxicity.  Amphetamines  were  synthesized  in  1887,  and  in  1932,  they  were  marketed  medicinally  in  an  inhaler  form  as  a  bronchodilator.  Use  of  methamphetamine  to  enhance  physical  and  intellectual  performance  began  in  the  1930s.  Amphetamines  were  widely  used  as  an  alertness  aid  for  troops  by  both  Allied  and  Axis  powers  during  World  War  II.  Today,  cocaine  and  amphetamines  have  limited  therapeutic  roles  but  are  widely  used  as  drugs  of  abuse.  Clinical  effects  and  toxicity  are  due  to  sympathetic  nervous  system  stimulation.