RT Book, Section
A1 Gresham, Chip
A1 LoVecchio, Frank
A2 Tintinalli, Judith E.
A2 Ma, O. John
A2 Yealy, Donald M.
A2 Meckler, Garth D.
A2 Stapczynski, J. Stephan
A2 Cline, David M.
A2 Thomas, Stephen H.
SR Print(0)
ID 1166599879
T1 Barbiturates
T2 Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260019933
LK accessmedicine.mhmedical.com/content.aspx?aid=1166599879
RD 2024/04/24
AB Barbiturates  are  still  the  most  common  class  of  antiepileptic  drugs  used  in  developing  countries,  but  their  use  is  declining  due  to  the  introduction  of  safer,  less  toxic  sedative-hypnotics  (e.g.,  benzodiazepines)  and  second-generation  anticonvulsants.1  Status  epilepticus,2  severe  ethanol  and  sedative  withdrawal  syndromes,3-5  and  toxicologic  seizures6  are  typically  managed  with  benzodiazepines,  but  barbiturates  have  a  useful  role  as  second-line  agents.  They  are  still  used  in  combination  drugs  (e.g.,  butalbital)  and  alone  (e.g.,  secobarbital)  for  the  treatment  of  tension  and  migraine  headaches7-9  and  for  refractory  intracranial  hypertension  from  focal  and  diffuse  brain  injury.10