RT Book, Section
A1 Al-Kindi, Salam
A1 McKinley-Grant, Lynn
A1 Sode, Titilola
A2 Kelly, A. Paul
A2 Taylor, Susan C.
A2 Lim, Henry W.
A2 Serrano, Ana Maria Anido
SR Print(0)
ID 1161549260
T1 Sickle Cell Disease
T2 Taylor and Kelly's Dermatology for Skin of Color, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071805520
LK accessmedicine.mhmedical.com/content.aspx?aid=1161549260
RD 2024/04/19
AB KEY  POINTSSickle  cell  disease  (SCD)  is  prevalent  in  sub-Saharan  Africa,  the  Middle  East,  India,  and  most  tropical  climates  where  malaria  is  present.The  SCD  group  of  disorders  can  include  all  genotypes  (eg,  HbSS,  HbSC,  and  HbSβ-thalassemia),  unlike  sickle  cell  anemia  which  occurs  only  with  the  HbSS  genotype.  SCD  is  characterized  by  recurrent  vaso-occlusive  crises,  anemia,  and  a  predisposition  for  infections.Patients  with  SCD  commonly  present  with  jaundice  and/or  pallor.A  physical  examination  of  the  patient  should  include  nonpathognomonic  skin  findings,  stroke,  pectus  excavatum,  body  habitus,  and  an  enlarged  spleen,  as  well  as  the  cutaneous  symptoms  of  renal  failure  (see  Chapter  73,  Renal  Disease).Leg  ulcers  are  a  common  cutaneous  manifestation  of  SCD.In  children,  hand-foot  syndrome  (dactylitis)  is  typically  the  first  cutaneous  marker  of  this  condition.