RT Book, Section A1 Ghannoum, Mahmoud A1 Salem, Iman A1 Christensen, Luisa A2 Kang, Sewon A2 Amagai, Masayuki A2 Bruckner, Anna L. A2 Enk, Alexander H. A2 Margolis, David J. A2 McMichael, Amy J. A2 Orringer, Jeffrey S. SR Print(0) ID 1161343881 T1 Antifungals T2 Fitzpatrick's Dermatology, 9e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071837798 LK accessmedicine.mhmedical.com/content.aspx?aid=1161343881 RD 2023/09/23 AB AT-A-GLANCETopical agents should be used for superficial fungal infections of limited extent.Topical agents have the advantage of low cost, nonprescription availability, ease of use, and high patient compliance.Topical antifungals include imidazoles, allylamines, benzylamines, polyenes, and ciclopirox.A number of new carrier vehicles have been investigated to improve the bioavaliabilty of topical antifungals.Systemic agents should be used to treat onychomycosis and tinea capitis, or when superficial fungal infection affects a large surface area.Attention should be paid to drug–drug interactions when prescribing systemic antifungals.Combination therapy with topical and systemic drugs presents several advantages.