RT Book, Section
A1 Goh, Chee Leok
A1 Pan, Jiun Yit
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161343635
T1 Dapsone
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK accessmedicine.mhmedical.com/content.aspx?aid=1161343635
RD 2024/04/16
AB AT-A-GLANCEDapsone  (4,4′-diaminodiphenylsulfone)  is  a  sulfonamide  with  unique  pharmacologic  action.It  is  used  as  an  antiinfective  in  particular  against  Hensen  disease  and  selected  fungal  infections  such  as  actinomycetoma  and  rhinosporidiosis.  It  is  also  used  for  the  treatment  of  malaria  and  as  a  prophylaxis  for  toxoplasmosis.It  is  also  an  antiinflammatory  agents  and  is  effective  against  dermatitis  herpetiformis,  erythema  elevatum  diutinum,  linear  immunoglobulin  A  dermatosis  and  chronic  bullous  disease  of  childhood,  and  bullous  eruption  of  systemic  lupus  erythematosus.It  has  antineutrophilic  effect  and  used  against  collagen  vascular  and  autoimmune  diseases  and  recently  topically  for  acne.It  is  often  used  as  corticosteroid-sparing  agent.Significant  side  effects  to  watch  for  include  hemolysis  and  methemoglobinemia,  which  are  frequently  observed  in  patient  with  glucose-6-phosphate  dehydrogenase  (G6PD)  deficiency.  Dapsone  should  only  be  given  with  great  caution  and  in  very  special  circumstances  to  patients  with  G6PD  deficiency  when  the  benefits  outweigh  the  risks  when  constant  hemoglobin  and  monitoring  of  reticulocyte  counts  is  essential.Other  serious  side  effects  include  drug  hypersensitivity  syndrome  (sulphone  syndrome),  Stevens-Johnson  syndrome,  and  agranulocytosis.Dapsone  is  classified  as  C  Pregnancy  Category  (ie,  risk  not  ruled  out).